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No Most studies with Glycoprotein IIb/IIIa inhibitors showed safety with unfractionated heparin. In fact, PRISM -PLUS showed possible excess mortality in the tirofiban without heparin arm (11). However, current data do not support the use of IIb/IIIa agents in patients who meet thrombolytic criteria unless they are getting percutaneous intervention and stent placement. This may be a future area to explore.
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