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Effect of Dietary Sodium Intake on Blood Lipids. Results From the
DASH-Sodium Trial |
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[epub ahead of print] [Record Supplied By Publisher]Hypertension 2004 Jan 5; pUnknown Paragraph TypeS1524-4563Unknown ParagraphType
Harsha DW; Sacks FM; Obarzanek E; Svetkey LP; Lin PH; Bray GA; Aickin M;
Conlin PR; Miller III ER; Appel LJ [Find other articles with these Authors]
Pennington Biomedical Research Center, Baton Rouge, La;
Endocrine-Hypertension Division and Channing Laboratory, Department of
Medicine, Brigham and Women's Hospital and Harvard Medical School and
Nutrition Department, Harvard School of Public Health, Boston, Mass;
National Heart, Lung, and Blood Institute, Bethesda, Md; Duke Hypertension
Center and the Sarah W. Stedman Nutrition and Metabolism Center, Duke
University School of Medicine, Durham, NC; Kaiser Permanente Center for
Health Research, Portland, Ore; and Welch Center for Prevention,
Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore,
Md.
We evaluated the effect on serum lipids of sodium intake in 2 diets.
Participants were randomly assigned to a typical American control diet or
the Dietary Approaches to Stop Hypertension (DASH) diet, each prepared with
3 levels of sodium (targeted at 50, 100, and 150 mmol/d per 2100 kcal). The
DASH diet is increased in fruits, vegetables, and low-fat dairy products and
is reduced in saturated and total fat. Within assigned diet, participants
ate each sodium level for 30 days. The order of sodium intake was random.
Participants were 390 adults, age 22 years or older, with blood pressure of
120 to 159 mm Hg systolic and 80 to 95 mm Hg diastolic. Serum lipids were
measured at baseline and at the end of each sodium period. Within each diet,
sodium intake did not significantly affect serum total cholesterol, LDL
cholesterol, HDL cholesterol, or triglycerides. On the control diet, the
ratio of total cholesterol-to-HDL cholesterol increased by 2% from 4.53 on
higher sodium to 4.63 on lower sodium intake (P=0.04). On the DASH diet,
sodium intake did not affect this ratio. There was no dose-response of
sodium intake on serum lipids or the cholesterol ratio in either diet. At
each sodium level, total cholesterol, LDL cholesterol, and HDL cholesterol
were lower on the DASH diet versus the typical American diet. There were no
significant interactions between the effects of sodium and the DASH diet on
serum lipids. In conclusion, changes in dietary sodium intake over the range
of 50 to 150 mmol/d did not affect blood lipid concentrations.
Language: English
MEDLINE Indexing Date: 200400
Publication Type: ;
Publication Type: JOURNAL ARTICLE
PMID: 0014707154
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