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Friday, September 05, 2008
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RISKS
ASSOCIATED
WITH TRANSFUSION
It has been argued that AIDS among
transfusion recipients is due to underlying diseases that necessitated the transfusion,
rather than to HIV (Duesberg, 1991). This theory is contradicted by a report by
the Transfusion Safety Study Group, which compared HIV-negative and HIV-positive
blood recipients who had been given transfusions for similar diseases. Approximately
three years after the transfusion, the mean CD4+ T cell count in 64 HIV-negative
recipients was 850/mm3, while 111 HIV-seropositive individuals had average CD4+
T cell counts of 375/mm3 (Donegan et al., 1990). By 1993, there were 37 cases
of AIDS in the HIV-infected group, but not a single AIDS-defining illness in the
HIV-seronegative transfusion recipients (Cohen, 1994d).
People have received blood transfusions
for decades; however, as discussed above, AIDS-like symptoms were extraordinarily
rare before the appearance of HIV. Recent surveys have shown that AIDS-like
symptoms remain very rare among transfusion recipients who are HIV-seronegative
and their sexual contacts. In one study of transfusion safety, no AIDS-defining
illnesses were seen among 807 HIV-negative recipients of blood or blood products,
or 947 long-term sexual or household contacts of these individuals (Aledort
et al., 1993).
In addition, through 1994, the CDC
had received reports of 628 cases of AIDS in individuals whose primary risk
factor was sex with an HIV-infected transfusion recipient (CDC, 1995a), a finding
not explainable by the "risk-AIDS" hypothesis.
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